甲状腺機能異常者における血清Myoglobin, Creatine PhosphokinaseおよびLactic Dehydrogenasel貝掟の診断的意義

概要

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Since muscle dysfunction is frequently associated with a hypothyroid state, many clinical reports have indicated that serum enzyme activities derived from the muscle such as creatine phosphokinase (CPK), lactic dehydrogenase (LDH) and glutamic-oxaloacetic transaminase (GOT) are elevated. These enzyme activities in the serum of hyperthyroidism, euthyroidism and hypothyroidism have been known to have a good inverse correlation with protein-bound iodine (PBI). Therefore, as part of a study of the relationship between thyroid states and muscle tissue, values of serum myoglobin (Mb) were measured by RIA. <BR>The values of Mb in untreated hyperthyroidism were significantly lower (p<;0.01) and, in untreated hypothyroidism, Mb values were significantly higher (p<0.001) than in normal subjects. There was a significant inverse correlation (p<0.01) between T4 or T3 concentration and Mb levels in these subjects. The relationship found between either Mb and LDH or Mb and CPK was also studied in the present study, and it was found that Mb significantly correlated to both LDH and CPK (p<0.001). Abnormalities of these enzyme levels in serum returned to the normal range rapidly after the correction of the abnormal thyroid states in each patient.
日本内分泌学会の論文