TXA<SUB>2</SUB>合成阻害剤投与およびハルトマン液による頭蓋内洗滌:-症候性脳血管攣縮の予防-

概要

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An attempt was made to prove clinically one of our contentions, that subarachnoid perivascular acidosis may play a role in the pathogenesis of cerebral vasospasm.<BR>Clinical results of 51 patients treated both with TX synthetase inhibitor to prevent cerebral vasospasm and with pH8.0 Hartmann solution for intracranial irrigation at operation, were compared with those of 82 patients in the previously performed cooperative clinical study of prevention of cerebral vasospasm with OKY-046.<BR>The ratio of patients in the present series operated on during the vasospasm predilection period (4-11th SAH day) was nearly twice that of the OKY-046 study. Incidences of both angiographic and symptomatic vasospasms were definitely lower in the present series. One month after the aneurysmal rupture, the percentage of patients with outcome graded excellent was higher, and the percentage of patients who had died was lower, in the present series.
The Japanese Society on Surgery for Cerebral Strokeの論文