虚血性脳循環障害患者の血液レオロジーおよび凝固線溶系に対するフルナリジンの効果

概要

論文の詳細を見る
Hemorheological changes and complete peripheral blood count before and after flunarizine (FLN) administration (10mg/day for 4 weeks) to the 12 patients with ischemic brain disease were studied to evaluate the mechanism of the therapeutic effects. The characteristics of the patients were 11 complete cerebral infarctions and 1 RIND, 9 males and 3 females, and age (mean ± SD) was 62.3±10.7 years old. The indices were blood passage time of whole blood, 40%HCT RBC suspension and plasma by Nuclepore® filtration method, the blood viscosity by using cone-plate type rotating viscometer (shear rate 18.8-375.0/sec) under the temperature of 37°C. In addition the CBC, fibrinogen, PT, APTT, α <SUB>2-</SUB>PI, AT-III, plasminogen and platelet aggregation test induced by collagen were measured. The obtained results were follows : 1) Whole blood passage time (WBPT) and 40%HCT RBC supension passage time (40%RBC PT) were shortened singnificantly (p<0.05) after FLN administration, although there were no difference in plasma passage time and blood viscosity. 2) Activity of plasminogen decreased singnificantly (p<0.05) after FLN administration. 3) Other indices showed no obvious difference. Shortening of WBPT and 40%RBC PT suggested that FLN caused the increase in the deformability of erythrocytes and would improve the microcirculation of the damaged brain tissue. (J. Jpn. Soc. Biorheol., 2 (3), 135-141, 1988).
特定非営利活動法人日本バイオレオロジー学会の論文

虚血性脳循環障害患者の血液レオロジーおよび凝固線溶系に対するフルナリジンの効果

スポンサーリンク

概要

著者

関連論文

スポンサーリンク