Norepinephrineと高濃度K保生液による収縮イヌ腎動脈の力学的特性の差異
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<I>In vitro</I> experiments were performed to investigate mechanical properties of relaxed and contracted arterial walls by using cylindrical segments from dog renal arteries. Vasoconstriction was produced by the addition of norepinephrine (NE) to KRS (Krebs-Ringer solution) and by a high K<SUP>+</SUP> KRS where K<SUP>+</SUP> was substituted for Na<SUP>+</SUP> on an equimolar basis. Diameter changes were measured when the transmural pressure was increased from 0 to 180mmHg at a speed of 0.75mmHg/sec. Pressure and diameter (<I>P-D</I>) relationship obtained in the normal KRS (relaxed state) showed a typical J-shaped curve. Activation of vasucular smooth muscle cells by NE and high K<SUP>+</SUP> altered this relashionship. NE- and high K<SUP>+</SUP>- induced contraction produced an N-shaped <I>P-D</I> curve and a linear-type <I>P-D</I> relationship, respectively. From thus obtained <I>P-D</I> curves, we calculated the pressure-strain elastic modulus (<I>E<SUB>p</SUB>=DdP/dD</I>) and the modified stiffness parameter (<I>β"=(D<SUB>s</SUB>/P)/(dD/dP)</I>). We also fitted data to the logistic-type equation including four parameters, <I>D<SUB>min</SUB></I>, <I>D<SUB>max</SUB></I>, <I>M</I> and <I>E</I>, which was given as<BR><I>D=D<SUB>min</SUB>+D<SUB>max</SUB>-D<SUB>min</SUB>/1+Mexp (-P/E)</I><BR>The observed differences of <I>P-D</I> curves between the relaxed and two contracted states were demonstrated by respective pressure dependences of <I>E<SUB>p</SUB></I> and β". The disparities were also attributed to the difference in the magnitude of parameters <I>M</I> and <I>E</I>.
- 特定非営利活動法人 日本バイオレオロジー学会の論文
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- Norepinephrineと高濃度K保生液による収縮イヌ腎動脈の力学的特性の差異