Estrogenのラット血中cholesterol低下作用発現に関する下垂体の役割
スポンサーリンク
概要
- 論文の詳細を見る
It was confirmed that the three estrogens, estradiol, estriol and hexestrol, produced marked decreases in both plasma cholesterol and phospholipids levels in intact rats. Also, it was found that the hypocholesterolemic activity of estrogens gradually decreased after hypophysectomy, and completely disappeared 9 days after the operation. Neither adrenalectmy, castration, nor thyroidectomy affected the manifestation of this estrogen action. The estrogen effect was manifested again when the hypophysectomized rats were primed with pituitary homogenate of the same species or bovine growth hormone before the estrogen treatment. The piming with TSH, HCG or PMS produced no restoration of the estrogen action which disappeared in the hypophysectomized animals. ACTH had no action on the plasma cholesterol level in intact rats, but produced marked increase in the hypophysectomized rats. This ACTH-induced hypercholesterolemia in the hypophysectomized animals was reduced to the normal level by the simultaneous treatment of estrogen. The estrogen action manifested also in rats treated with prednisolone, the dosage of which was enough to produce complete suppression of ACTH secretion.<BR>These facts suggest that the pituitary is necessary for the manifestation of hypocholesterolemic action of estrogen in rats, and that growth hormone may play an important role in the lipid-shifting action of estrogen, while ACTH may be not a factor directly related to this estrogen action.
- 一般社団法人 日本内分泌学会の論文
著者
関連論文
- 11 肝切除後における胆汁中胆汁酸の変化(第14回日本消化器外科学会総会)
- チオアセトアミド肝硬変ラットにおける肝切除前後の胆汁酸代謝に関する研究
- 175 硬変肝部分切除後の胆汁酸代謝に関する実験的検討(第19回日本消化器外科学会総会)
- Platelet Aggregation Inhibitors in a Bhutanese Medicinal Plant, Shug Chher
- Platelet Aggregation Inhibitors from Populus sieboldii MIQUEL
- Platelet Aggregation Inhibitors and Inotropic Constituents in Pyrolae Herba
- A Novel Class of Platelet Activating Factor (PAF) Antagonists. II. Modification of the 2-Position of the Glycerol Backbone of PAF-Sulfonamide Isosteres
- A Novel Class of Platelet Activating Factor (PAF) Antagonists. I. Synthesis and Structure-Activity Studies on PAF-Sulfonamide Isosters
- 6. 胆道閉鎖症の肝組織に認められたレオ 3 型ウイルス関連抗原(第 16 回胆道閉鎖症研究会)
- W-I-3 胆道閉鎖症の肝組織に認められたレオ3型ウイルス関連抗原
- Studies on Choleretic Consituents in Artemisia capillaris THUNB.
- ヨモギ属植物の利胆作用
- 60 胆嚢壁の炎症の程度による胆汁中胆汁酸組成変化(第12回日本消化器外科学会総会)
- Determination of Glycated Proteins in Biological Samples Based on Colorimetry of 2-Keto-glucose Released with Hydrazine
- A Novel Colorimetric Method for Determination of Glycated Protein Based on 2-Keto-glucose Release with Hydrazine
- 2-I-2新生児・幼若乳児ならびに抗生剤投与患者の肝組織中ビタミンK含量 : 第44回研究発表要旨
- ビタミンK(V.K)の人の下部腸管からの吸収について : 第40回大会研究発表要旨
- β-ラクタム抗生剤とビタミンK代謝 : 日本ビタミン学会 : 第39回大会研究発表要旨
- 消化管穿孔による汎発性腹膜炎時の血中フォスフォリパーゼA
- β-ラクタム抗生剤とビタミンK代謝 : 第2報 : 第40回大会研究発表要旨
- アロキサン糖尿ラットにおける血中脂質およびリポ蛋白値の変化--1年にわたる経過検討
- 新規トロンボキサン A2 拮抗薬，S-145 の血小板凝集に対する作用
- 胆汁酸の生合成とコレステロール代謝との関係
- 腸内細菌と胆汁酸代謝
- 諸種estrogenの去勢雄ラットの血漿cholesterol及びphospholipidに対する作用態度の相違について
- ラット血漿cholesterol値に対するestrogenの二相性効果について
- Regulation of Serum Cholesterol Level by the Liver:Relationship with Development of Hypercholesterolemia, Aging and Genetic Factor
- Subcellular Distribution of Cholesterol in the Intestine and Liver and the Effect of Feeding of High Cholesterol Diet
- Estrogenのラット血中cholesterol低下作用発現に関する下垂体の役割