歴代雌, 雄甲状腺機能異常ウサギより生まれた子孫ウサギ (F<SUB>1</SUB>, F<SUB>4</SUB>, F<SUB>5</SUB>) の血清蛋白分画像に関する研究
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Paper electrophoresis studies were made on the serum protein fractions in rabbits given powdered thyroid gland (30 mg/kg every day, per os) or undergoing thyroidectomy, and in the offspring of rabbits (F<SUB>1</SUB>, F<SUB>4</SUB>, F<SUB>5</SUB> ; these were not given powdered thyroid gland nor did they undergo thyroidectomy) descended from ancestors given powdered thyroid gland (30 mg/kg every day for one month, per os) or undergoing thyroidectomy (more than one month after operation) over several successive generations. Compared with normal values, the results were as follows.<BR>1) Average values in 8 normal rabbit sera (4 female, 4 male) were ; albumin 60.7±1.7%, a-globulin 13.0 ±2.0%, β-globulin 12.2 ±2.1% and γ-globulin 14.1±1.9%. Total protein values were 6.39±0.24g/d1.<BR>2) Alterations presented with the passage of time after the administration of powdered thyroid gland in normal rabbits were, albumin was markedly decreased, a-globulin and γ-globulin increased after 10 days and after that continued similar changes. Changes after thyroidectomy schowed gradually a decrease in albumin and an increase in β-globulin, and these findings became more evident as time passed.<BR>3) Serum protein fractions in offspring of rabbits (F<SUB>1</SUB>, F<SUB>4</SUB>, F<SUB>5</SUB>) administered powdered thyroid gland over successive generations showed a decrease in albumin and an increase in a-globulin, and these changes seemed more and more evident as the generations progressed, and resembled the values in rabbits given powdered thyroid gland.<BR>4) Serum protein fractions in offspring of rabbits (F<SUB>1</SUB>, F<SUB>4</SUB>) undergoing thyroidectomy over successive generations showed a decrease in albumin, a slight increase in α-globulin and an increase in β-globulin. These changes also seemed more evident as the generation progressed, and resembled the values of rabbits after thyroidectomy.
- 日本内分泌学会の論文
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