歴代両親実験的糖尿病子孫ウサギ (F1～F5) にAlloxan糖尿病を発症させたさいの血清蛋白, 複合蛋白ならびに血中総コレステロールについて

概要

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Alloxan diabetes was induced by means of alloxan administration in the offspring of rabbits (F1-F5, 2-3 cases of each generation) descended from rabbits with induced diabetes (persisted for more than one month) over successive generations. Afetr about 100 days, serum protein, lipoprotein, glycoprotein were analysed by paperelectrophoresis. Total blood cholesterol levels, blood sugar levels and total protein values were measured also. Compared with normal values (12 cases), the results were as follows. 1) Serum protein fractions showed a marked decrease in albumin and an increase in α2-globulin and γ-globulin. The degree of increase in α2-globulin became more and more significant as the generations progressed. The lipoprotein index increased in each generation. Glycoprotein fractions showed changes analogous to those of the protein fractions. 2) Total cholesterol levels were slightly increased in F4 and F5. Blood sugar levels were markedly increased in every generation. Total serum protein values were normal. 3) It is concluded that the serum protein, lipoprotein and glycoprotein patterns in these rabbits showed changes before alloxan administration, and presented moreover changes seen in alloxan diabetic rabbits. 4) These alterations are similar to those in a few cases of human diabetes.
日本内分泌学会の論文