GlycyrrhizinのCorticoid作用の本態に関する実験的研究
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A study is made of effects of glycyrrhizin on the metabolism of hydrocortisone using rat liver homogenate or its supernatant.<BR>The result obtained are as follows : <BR>1. Glycyrrhizin inhibited the degradation of sidechain as well as the reduction of <I>Δ</I><SUB>4</SUB>-3 ketone.<BR>2. Glycyrrhezinic acid was found to be the very agent to inhibit the metabolism of hydrocortisone.<BR>3. Glycyrrhizin had no effect upon the degradation of sidechain of tetrahydrohydrocortisone. It is assumed that glycyrrhizin specifically inhibited the reduction of <I>Δ</I><SUB>4</SUB>-3 ketone and acted indirectly upon the degradation of sidechain.<BR>4. Glycyrrhizin also inhibited the reduction of <I>Δ</I><SUB>4</SUB>-3 ketone of DOC and progesterone.<BR>5. It is suggested that glycyrrhizin inhibit competitively the metabolism of corticoid and manifest a corticoid-like action.
- 日本内分泌学会の論文
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