Impact of Mild to Moderate Renal Dysfunction on Left Ventricular Relaxation Function and Prognosis in Ambulatory Patients With Nonischemic Dilated Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between mild-to-moderate renal dysfunction and cardiac diastolic dysfunction and cardiac events in patients with nonischemic dilated cardiomyopathy (NDCM) has not been fully elucidated. The aim of this study was to investigate the relationship between renal and cardiac function, as well as clinical outcome in patients with NDCM.We measured plasma BNP and eGFR, and performed cardiac catheterization in 135 patients with NDCM. LV dP/dtmaxand T1/2 were determined as indexes of LV contractility and isovolumic relaxation, respectively. During a mean follow-up of 4.8 years, we monitored all patients for the occurrence of cardiac events, which were defined as cardiac death (from worsening HF or sudden death) and unscheduled admission for decompensated HF. Patients were classified into 3 groups on the basis of eGFR (mL min-1 1.73 m-2): eGFR ≥ 90 (n = 23, group A), 60 ≤ eGFR < 90 (n = 70, group B), and 30 ≤ eGFR < 60 (n = 42, group C). Whereas LV dP/dtmax did not significantly differ among the 3 groups, T1/2 was significantly longer in groups B and C than in group A (P < 0.01). Event-free survival in group C was significantly lower than that in groups A and B (P = 0.014, log-rank test). These results suggest that even mild renal dysfunction is associated with LV isovolumic relaxation impairment. In addition, moderate impairment of renal function is independently associated with cardiac events in patients with NDCM.
著者
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Funahashi Hidehito
Department of Cardiology, Nagoya University Graduate School of Medicine
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Ohshima Kei
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Ohshima Satoru
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Funahashi Hidehito
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Hayashi Mutsuharu
Department Of Cardiology Nagoya Medical Center
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Sakakibara Masaki
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Cheng Xian
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Murohara Toyoaki
Department Of Cardiology Nagoya Graduate School Of Medicine
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Hirashiki Akihiro
Department Of Advanced Medicine In Cardiopulmonary Disease Nagoya University Graduate School Of Medicine
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Okumura Takahiro
Department of Cardiology, Nagoya University Graduate School of Medicine
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Hayashi Daiske
Department of Cardiology, Nagoya University Graduate School of Medicine
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