Association of Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acid Ratio with Complexity of Coronary Artery Lesion
スポンサーリンク
概要
- 論文の詳細を見る
Objective Eicosapentaenoic acid (EPA) of the omega-3 polyunsaturated fatty acids (ω-3 PUFA) family plays important roles in the prevention of cardiovascular disease (CVD), while, arachidonic acid (AA) of the ω-6 PUFA family promotes inflammatory and prothrombotic influences. The complexity of coronary lesions represents the vulnerability of patients. The aim of this study was to investigate the association between the plasma EPA/AA ratio and the prevalence of complex coronary lesion morphology. Methods This study consisted of 206 consecutive patients with stable angina pectoris (sAP). Each coronary lesion was determined either as complex or simple based on angiographic findings. To examine the plasma fatty acid level, blood samples were obtained. Patients were divided into three groups according to the obtained plasma EPA/AA ratio: the highest tertile, n=67, the 2nd tertile, n=70, or the lowest tertile, n=69. Results A higher incidence of complex coronary lesion was obtained from patients with a lower plasma EPA/AA ratio [43 (62%) vs. 31 (44%) vs. 25 (37%), p=0.011]. High-sensitivity CRP levels and a low plasma EPA/AA ratio could independently predict the prevalence of complex coronary lesions on multivariate logistic regression analysis [odds ratio 1.83 (95%CI 1.03-3.25), p=0.038 and odds ratio 2.10 (95%CI 1.11-3.94), p=0.02)]. Conclusion In patients with sAP, a low plasma EPA/AA ratio was significantly associated with a high prevalence of complex coronary lesions.
著者
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Matsumoto Masaya
Department of Cardiology, Nagoya Daini Red Cross Hospital
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Yoshikawa Daiji
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Hayashi Mutsuharu
Department Of Cardiology Nagoya Medical Center
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Hayashi Kazunori
Department Of Cardiology Ogaki Municipal Hospital
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Amano Tetsuya
Department Of Cardiology Chubu-rosai Hospital
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Ando Hirohiko
Department Of Cardiology Chubu-rosai Hospital
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Ishii Hideki
Department Of Cardiology Nagoya Graduate School Of Medicine
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Murohara Toyoaki
Department Of Cardiology Nagoya Graduate School Of Medicine
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Hayakawa Seiichi
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Kumagai Soichiro
Department Of Cardiology Chubu-rosai Hospital
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Tanaka Miho
Department Of Applied Chemistry Aichi Institute Of Technology
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Sugiura Tsuyoshi
Department of Cardiology, Nakatsugawa Municipal General Hospital, Japan
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Amano Tetsuya
Department of Cardiology, Aichi Medical University, Japan
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Kumagai Soichiro
Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
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Hayashi Mutsuharu
Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
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