Prevalence of Activated Protein C Resistance in Acute Myocardial Infarction in Japan.
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概要
- 論文の詳細を見る
To investigate the possibility that activated protein C (APC) resistance due to the factor V could be an important predisposing factor in acute myocardial infarction (AMI), we have retrospectively examined the prevalence of APC resistance with protein C, protein S and antithrombin III deficiency and antiphospholipid antibody syndrome in AMI patients (_??_50 years) admitted to our hospital over the past 7 years. Forty-seven patients were enrolled in the study. We divided the patients into two groups, warfarin group (group A) and a non-warfarin group (group B). APC resistance is defined as when the APC ratio is below or equal to the cut-off value 2. APC resistance was not detected in either group. The prevalence of an APC ratio below or equal to 2.5 was 16.7% (1 case) in group A and 24.4% (10 cases) in group B. The prevalence of protein C deficiency was 5.0% (2 cases) in group B. Two cases (5.0%) in group B had protein S deficiency. Antithrombin III deficiency was not detected in either group. The prevalence of antiphospholipid antibody syndrome measured by APTT was 40.4% (19 cases). We compared the AMI patients with 97 healthy volunteers (_??_50 years old) without any thromboembolic events or bleeding tendency in their past history. No significant difference were found between these groups and the volunteers. APC resistance is a major cause of venous thromboembolism in Europe and the United States, while in Japan it is believed to be a minor cause of arterial thromboembolism.
- International Heart Journal刊行会の論文
著者
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Kondoh Junichiro
Department of Cardiology, Ogaki Municipal Hospital
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Sone Takahito
Department Of Cardiology Ogaki Municipal Hospital
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TOKI Yukio
Department of Internal Medicine II, Nagoya University School of Medicine
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Okumura Kenji
Department O Pediatrics Graduate School Of Medical Science Kumamoto University
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Numaguchi Yasushi
Department Of Cardiology Ogaki Municipal Hospital
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Hayakawa Tetsuo
Department Of Internal Medicine Ii Nagoya University School Of Medicine
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Tsuboi Hideyuki
Department Of Applied Chemistry Graduate School Of Engineering Tohoku University
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Hayashi Kazunori
Department Of Cardiology Ogaki Municipal Hospital
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Sassa Hiromi
Department Of Cardiology Ogaki Municipal Hospital
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Ito Takayuki
Department Of Cardiology Aichi Medical University
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Sassa Hiromi
Department of Cardiology, Ogaki Municipal Hospital
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NUMAGUCHI Yasushi
Department of Internal Medicine II, Nagoya University School of Medicine
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ITO Takayuki
Department of Internal Medicine II, Nagoya University School of Medicine
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OKUMURA Kenji
Department of Internal Medicine II, Nagoya University School of Medicine
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