Quinapril Prevents Restenosis After Coronary Stenting in Patients With Angiotensin-Converting Enzyme D Allele
スポンサーリンク
概要
- 論文の詳細を見る
Restenosis after coronary artery stent implantation is attributed chiefly to intimal hyperplasia, which is prevented experimentally by angiotensin-converting enzyme (ACE) inhibitors. Therefore, the present study investigated whether the effect of quinapril, a tissue-specific ACE inhibitor, on the prevention of coronary restenosis differs according to ACE polymorphism. One hundred consecutive patients with successful stent implantation were randomly assigned to quinapril and control groups. Both follow-up angiography and ACE polymorphism analysis were obtained from 92 patients (control, 46; quinapril treatment, 46). The prevalence of risk factors did not differ statistically according to quinapril treatment or ACE genotypes. There was no statistically significant difference in the occurrence of restenosis 6 months after stenting between the groups. Quantitative coronary angiography revealed that quinapril treatment resulted in significantly higher minimal lumen diameter and significantly lower percent diameter stenosis (22.9±22.6 vs 37.1±19.7% in the control group, p<0.05) in patients with the D allele although there was no difference in those with the II genotype. In addition, intravascular ultra-sound revealed that quinapril treatment significantly prevented the loss of minimal lumen cross-sectional area and the increase in percent area stenosis (34.5±14.0 vs 53.3±16.4% in the control group, p<0.05) in patients with the D allele compared to those with the II genotype. These results suggest that the administration of ACE inhibitors for the attenuation of lumen loss after coronary stent implantation is best for subjects with the D allele of the ACE genotype.
- 社団法人日本循環器学会の論文
- 2002-03-20
著者
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Sone Takahito
Department of Cardiology, Ogaki Municipal Hospital
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Tsuboi Hideyuki
Department of Cardiology, Ogaki Municipal Hospital
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Mukawa Hiroaki
Department of Cardiology, Ogaki Municipal Hospital
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Obata K
Department Of Cardiovascular Research Medicine Nagoya University School Of Medicine
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Tsuzuki Michitaka
Department of Cardiology, Nagoya University Graduate School of Medicine
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Kondoh Junichiro
Ogaki municipal Hospital
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Kondo Junichiro
Department of Cardiology, Ogaki Municipal Hospital
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Matsui Hideo
Internal Medicine 2, Nagoya University School of Medicine
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Okumura Kenji
Internal Medicine 2, Nagoya University School of Medicine
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Sone Takahito
Ogaki Municipal Hospital Department Of Cardiology
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Sone Takahito
Department Of Cardiology Ogaki Municipal Hospital
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Sone Takahito
Dept. Of Cardiology Ogaki Municipal Hospital
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Imai Hajime
Department Of Cardiology Nagoya University Graduate School Of Medicine
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HAYAKAWA Tetsuo
Internal Medicine II, Nagoya University Scool of Medicine
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Hayakawa Tetsuo
Internal Medicine Ii Nagoya University School Of Medicine
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Imai Hajime
Internal Medicine II, Nagoya University School of Medicine
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Kamiya Hiroki
Internal Medicine II, Nagoya University School of Medicine
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Mabuchi Yukio
Internal Medicine II, Nagoya University School of Medicine
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Matsui Hideo
Cardiovascular Center Social Insurance Chukyo Hospital
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Kondo Junichiro
Department Of Cardiology Ogaki Municipal Hospital
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Tsuboi Hideyuki
Department Of Applied Chemistry Graduate School Of Engineering Tohoku University
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Tsuboi Hideyuki
Department Of Cardiology Ogaki Municipal Hospital
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Tsuzuki Michitaka
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Okumura Kenji
Cardiovascular Research Medicine Nagoya University School Of Medicine
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Mukawa Hiroaki
Ogaki Municipal Hospital Department Of Cardiology
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Mabuchi Yukio
Internal Medicine Ii Nagoya University School Of Medicine
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Kamiya Hiroki
Internal Medicine Ii Nagoya University School Of Medicine
-
Mukawa Hiroaki
Department Of Cardiology Ogaki Municipal Hospital
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