Effects of Aged Garlic Extract on Left Ventricular Diastolic Function and Fibrosis in a Rat Hypertension Model
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概要
- 論文の詳細を見る
Daily consumption of garlic is known to lower the risk of hypertension and ischemic heart disease. In this study, we examined whether aged garlic extract (AGE) prevents hypertension and the progression of compensated left ventricular (LV) hypertrophy in Dahl salt-sensitive (DS) rats. DS rats were randomly divided into three groups: those fed an 8% NaCl diet until 18 weeks of age (8% NaCl group), those additionally treated with AGE (8% NaCl + AGE group), and control rats maintained on a diet containing 0.3% NaCl until 18 weeks of age (0.3% NaCl group). AGE was administered orally by gastric gavage once a day until 18 weeks of age. LV mass was significantly higher in the 8% NaCl + AGE group than in the 0.3% NaCl group at 18 weeks of age, but significantly lower in the 8% NaCl + AGE group than in the 8% NaCl group. No significant differences were observed in systolic blood pressure (SBP) between the 8% NaCl and 8% NaCl + AGE groups at 12 and 18 weeks of age. LV end-diastolic pressure and pressure half-time at 12 and 18 weeks of age were significantly lower in the 8% NaCl + AGE group compared with the 8% NaCl group. AGE significantly reduced LV interstitial fibrosis at 12 and 18 weeks of age. Chronic AGE intake attenuated LV diastolic dysfunction and fibrosis without significantly decreasing SBP in hypertensive DS rats.
- Japanese Association for Laboratory Animal Scienceの論文
著者
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Minoshima Makoto
Department Of Pathophysiology Laboratory Sciences Nagoya University Graduate School Of Medicine
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Sugiura Mari
Department Of Pathophysiology Laboratory Sciences Nagoya University Graduate School Of Medicine
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Miyata Seiko
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine
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Noda Akiko
Department Of Medical Technology Nagoya University School Of Health Science
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Nagata Kohzo
Department Of Medical Technology Nagoya University School Of Health Sciences
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Cheng Xian
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Furukawa Mayuko
Department Of Medical Technology Nagoya University School Of Health Science
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Murohara Toyoaki
Department Of Cardiology Nagoya Graduate School Of Medicine
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Kojima Jun
Department Of Crystalline Materials Science School Of Engineering Nagoya University
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Hara Yuki
Department of Medical Technology, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan
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Nagata Kohzo
Department of Medical Technology, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan
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Otake Masafumi
Department of Medical Technology, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan
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Murohara Toyoaki
Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan
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Minoshima Makoto
Department of Medical Technology, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan
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Kojima Jun
Department of Medical Technology, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan
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Furukawa Mayuko
Department of Medical Technology, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan
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Noda Akiko
Department of Biomedical Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan
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Miyata Seiko
Department of Biomedical Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan
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Sugiura Mari
Department of Medical Technology, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi 461-8673, Japan
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