Gelsenicine from Gelsemium elegans Attenuates Neuropathic and Inflammatory Pain in Mice
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概要
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Gelsemium elegans BENTH and its crude extract are widely used to treat pain in China despite its apparent toxicity. The analgesic effects of gelsenicine, an active component of G. elegans, however, have not been reported. The current study examined potential analgesic effects of subcutaneously injected gelsenicine using acetic acid-induced writhing, formalin-induced nociceptive behavior, and thermal hyperalgesia caused by chronic constriction injury (CCI) in mice. Gelsenicine produced dose-dependent analgesic effects in both inflammatory and neuropathic pain models. The ED50, for either the inflammatory pain (10.4 μg/kg for writhing test, 7.4 μg/kg for formalin test) or neuropathic pain (9.8 μg/kg for thermal hyperalgesia caused by CCI model), was far below the LD50 (95% confidence interval at 100—200 μg/kg). Repeated subcutaneous injections of gelsenicine in CCI mice led to sustained attenuation of neuropathic pain after drug discontinuation. These results revealed that gelsenicine could be used safely to attenuate both inflammatory and neuropathic pain.
著者
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Shen Jie
Department Of Cardiology Rui Jin Hospital
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Liu Hao
Department Of Applied Chemistry Seikei University
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Liu Ming
Department Of Internal Medicine University Of Michigan Medical School
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Yang Jian
Department Of Anesthesiology University Of Florida College Of Medicine
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Xu Ying
Department of Ecosystem Engineering, Graduate School of Engineering, The University of Tokushima
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Xu Ying
Department of Pharmacology, College of Pharmacy, Fujian Medical University
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Shen Jie
Department of Pharmacology, College of Pharmacy, Fujian Medical University
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Yu Chang-Xi
Department of Pharmacology, College of Pharmacy, Fujian Medical University
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Su Yan-Ping
Department of Pharmacology, College of Pharmacy, Fujian Medical University
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Liu Hao
Department of Pharmacology, College of Pharmacy, Fujian Medical University
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