Compositional Optimization and Safety Assessment of a Hydrogel Patch as a Transcutaneous Immunization Device
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概要
- 論文の詳細を見る
The development of a simple, easy-to-use, and non-invasive vaccination system is in high demand. For transcutaneous immunization (TCI), we previously developed a hydrogel patch formulation that accelerates the penetration of an antigen (Ag) through the stratum corneum (SC) and effectively elicits Ag-specific immune responses. The present studies were performed to optimize the composition and assess the safety of the patch formulation. A hydrogel patch with a water content ratio of 5% more effectively induced an immune response compared to patches with a different composition, suggesting that the moisture content of the hydrogel patch formulation has optimal ratio for SC hydration to promote Ag penetration through the SC. TCI using a hydrogel patch induced few local and systemic adverse reactions. Based on these results, we are now advancing translational research to evaluate the safety and efficacy of our novel TCI system in humans.
- 公益社団法人 日本薬学会の論文
著者
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MUKAI Yohei
Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation
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Asada Hideo
Department Of Dermatology Nara Medical University
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Okada Naoki
Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Nakagawa Shinsaku
Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Kamiyama Fumio
Cosmed Pharmaceutical Co. Ltd.
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Quan Ying-Shu
CosMED Pharmaceuticals Co., Ltd.
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Matsuo Kazuhiko
Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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Ishii Yumiko
Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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Mukai Yohei
Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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Kamiyama Fumio
CosMED Pharmaceuticals Co., Ltd.
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