常在菌感作,吸入による実験的過敏性肺臓炎

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Hypersensitity pneumonitis was developed in rabbits by inhalation of cell wall or supernatant of K. pneum. or Cl. perf. two weeks after single or multiple (once a week, 4 times) immunization of K. pneum. or Cl. perf. emulsified with incomplete Freund's adjuvant. The rabbits were sacrificed 3, 12, 48 hrs and 7 days after the inhalation of each antigen. In the group of rabbits received the single immunization and inhaled with cell wall, the pulmonary lesion showed interstitial granulomatous pneumonitis characterized by infiltra-tion of polymorphonuclear leukocytes (PMN) and predominantly mononuclear cells (MNC) in the alveolar septa and space and the granuloma formation. These findings were frequently observed on 48 hrs, thereafter gradually diminished. The rabbits in this group showed delayed type skin reaction (24 hrs) and also low titration of precipitating antibody against the immunized antigen. In the other group of rabbits received the multiple immunization and inhaled with cell wall, pneumonitis was characterized with severe infiltration of PMN and with mild infiltration of MNC. The findings were observed on 3 to 12 hrs. The rabbits in the group showed Arthus type skin reaction (8 hrs) and higher titration of precipitating antibody against the immunized antigen than the group of single immuniza-tion. In the group of rabbits inhaled with the supernatant after single or multiple immuniza-tion, PMN and interstitial thickening were observed almost same degree as that of cell wall inhalation, but infiltration of MNC was weak and granuloma formation was rare. From these data, we suggested as follows ; The lesion was induced by both of Arthus type and delayed type reaction due to inhalation of bacterial antigens. In addition, a part of cell wall component may play a main role for induction of allergic pneumonitis, comparing to that of supernatant.
学校法人昭和大学・昭和医学会の論文

常在菌感作,吸入による実験的過敏性肺臓炎

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