マウスの遅延型アレルギーに対する漢方薬の作用

概要

論文の詳細を見る
The effects of six kinds of kampo medicines used to treat contact dermatitis and atopic dermatitis (Oren-gedoku-to: OGT, Unsei-in: USI, Juzen-taiho-to: JTT, Keigai-rengyo-to: KRT, Toki-inshi: TI, Shimotsu-to: SMT) on acute and chronic dermatitis of delayed-type hypersensitivity (DTH), using contact hypersensitivity of a mouse models such as picryl chloride (PC) or oxazolone (Oxa) -induced DTH response, were studied. Acute lesions of PC or Oxa-induced DTH were produced by a single challenge of PC or Oxa in BALB/c or BDF<SUB>1</SUB> mice. Chronic lesions of Oxa-induced DTH were produced by four challenges of Oxa in BDF1 mice. Six kinds of kampo medicines reduced PC or Oxa-induced ear swelling. However, the effects of most of the kampo medicines were dose-independent responses. OGT, USI, JTT and KRT inhibited ear swelling in Oxa-induced chronic dermatitis. The increase of IgE in ear tissues of Oxa-induced chronic dermatitis was inhibited by administration of OGT, USI and JTT. These results suggest that OGT, USI, JTT and KRT improve acute and chronic dermatitis. The inhibition of ear swelling suggests that the effects of OGT. USI and JTT may be mediated through suppression of IgE production.