甲状腺原発扁平上皮癌の一症例

概要

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It is well known that primary Squamous cell carcinoma of the thyroid gland is rare and the prognosis poor. Incidence of this disease is said to be about 1% of all thyroid carcinomas. From 1966-1977, we operated on 71 patients with thyroid carcinomas. One case concerned a 60-year-old woman in whom a Squamous cell carcinoma of the thyroid gland had occurred. Besides squamous cell carcinoma, Hashimoto's disease and follicular adenocarcinoma of the thyroid gland were found in detailed histological examinations. Therefore this squamous cell carcinoma of the thyroid gland was considered to arise from squamous metaplasia of follicular adenocarcinoma, that is from adenoacanthoma.The incidence, treatment, prognosis and mainly histogenesis of squamous cell carcinoma of the thyroid gland are discussed. Three courses of histogenesis are postulated, the first is that squamous cell carcinoma of the thyroid gland arises from a congenital aberrant squamous epithelium, the second is that it is due to a squamous metaplasia of follicular epithelium, and the third that it is the result of a squamous metaplasia of adenocarcinoma. The third postulation was considered to be the most probable.