頭頚部悪性腫瘍患者における免疫機能の動態について-1-

概要

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Immunological investigation on cancer has become most popular in recent years. In the present study, we looked into changes in the T-cell rosette test of peripheral blood and the blastformation rate of lymphocytes as a method for examining the immunological function of cancer patients.The subjects were 25 cases of malignant tumors in the head and neck. Studies were made on what change the clinical picture of cancer in the course of treatment would bring about in the immunological function of these patients. We found that the percent peripheral T-cell of cancer patients was lower on the average than that of non-cancer patients. In cases where the tumor had diminished or disappeared by radiation, intra-arterial infusion of carcinostatic agents (Bleomycin, Carboquone) and/or surgical treatment, the percent peripheral T-cell tended to rise with advance of the treatment. In cases of tumor enlargement and OK-432 was being administered, the percent peripheral T-cell had once fallen off in the middle of the course of the treatment and rose again by the end of the treatment.Regarding the blastformation rate of lymphocytes, there was no fixed tendency so far as changes during the clinical course are concerned.
耳鼻咽喉科臨床学会の論文