Inhibitory Effects on Metastasis of Combination Therapy with Biological Response Modifiers.
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The inhibition of metastasis by combination therapy with biological response modifiers was studied in C57BL/6 mice with transplanted EL-4 lymphomas. The effects of recombinant interleukin 2 (rIL-2) and/or Sizofiran (SPG) were evaluated from the histopathological findings in H-E stained and monoclonal antibody stained specimens. The combined administration of rIL-2 and SPG resulted in 1) fewer tumor cells, 2) more prominent lymphocyte infiltration, and 3) more anti-tumor effector cells and helper cells than did that of rIL-2 alone or SPG alone, or neither.
- 耳鼻咽喉科臨床学会の論文
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