Recurrent Subacute Thyroiditis Associated with Liver Dysfunction; A Case Report.

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It is generally accepted that subacute thyroiditis is a self-limited inflammatory disease of the thyroid gland, characterized by severe pain and tenderness on the thyroid gland, transient thyrotoxicosis, erythrocyte sedimentation rate elevation, systemic manifestations of inflammation such as malaise, fever and fatigue. It recurs in about 10-20% of patients. Some authors have reported cases of subacute thyroiditis with liver dysfunction, such as elevation of transaminase (glutamic oxalacetic transaminase-GOT, glutamic pyruvic transaminase-GPT) and alkaline phosphatase. These abnormalities were all reduced in the course of therapy, and none of patients showed recurrent subacute thyroiditis or liver dysfunction. In this report, we present a case of subacute thyroiditis associated with liver dysfunction which progressed and improved in parallel wite the thyroiditis. The serum antibody titer against Coxsackie A virus was elevated, and Coxsackie A virus was suspected to be the etiological agent.