上咽頭悪性リンパ腫の病因として : EBウイルスが考えられた1症例

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A case of EBNA-positive non-Burkitts lymphoma of the nasopharynx is reported.The patients was 19-year-old female who complained of headache and bilateral cervical lymphoadenopathy for the past one month. Otolaryngological examination revealed a tumor on the lateral and superior wall of the nasopharynx. The tumor was histologically diagnosed as non-Hodgikins lymphoma (non-Burkitts type). Serologically, viral capsid antigen and early antigen to Epstein-Barr virus were 640-fold and 40-fold, respectively. EBNA was also detected in the biopsy specimen by anti-complement immunfluorescent test.The patient was treated by irradiation with a dose of 4, 000 rads to the nasopharynx. Also, 4, 000 rads were given to the whole neck, mediastinum and bilateral axillary region. Combination chemotherapy using bleomycin, vincristine, cyclophosphamide and adriamycin was also concurrently performed. She is doing well 3 months after the treatment.
社団法人日本耳鼻咽喉科学会の論文