Malignant Melanoma in Ethmoid Sinus; A Case Report.

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We treated a patient with ethmoid sinus malignant melanoma by both intracranial and facial surgery.Case: A 49-year-old woman complained of right nasal obstruction and nasal bleeding for three months. A light pink tumor was seen in the right nasal meatus. Hematoxylineosin stained intranasal biopsy specimens of the mass suggested malignant melanoma, and Fontana-Masson and S-100 protein stains confirmed the diagnosis. Surgery was performed first both cranial and facial, to resect the tumor along with the contents of the right orbit, the anterior skull base and the right hard palate. The defect was reconstructed with a free abdominal flap only. Postoperatively she was treated with chemotherapy (DTIC, ACNU and Vincristin) and immunotherapy (IFN).This patient has been followed for 2 years and shows no evidence of recurrence of the disease.
耳鼻咽喉科臨床学会の論文