Chondronecrosis of the Thyroid Cartilage Following Intra-arterial Chemotherapy.

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Chondronecrosis of the laryngeal cartilage is a rare condition, usually occurring as a complication following radiation therapy. We report an unusual case which occurred not after radiation therapy, but with local infection following intra-arterial chemotherapy.The patient was a 67-year-old male with a carcinoma of the left upper gingiva. He received local radiation therapy of 40 Gy to the left maxilla in conjunction with intra-arterial chemotherapy through the superior thyroid artery. Soon after discharge from the hospital. He developed dyspnea and dysphagia. Tracheostomy was performed to relieve the patient's dispnea, but the underlying cause of his problem remained unknown. Following a hemilaryngectomy, the surgical specimen revealed chondronecrosis of the thyroid cartilage caused by local infection during arterial infusion.The most probable cause of the chondronecrosis in this patient was perichondritis of the thyroid cartilage.