血管条血管へのステロイドホルモンの影響

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When anesthetized guinea pigs which have been injected with horseradish peroxidase (HRP) are killed by decapitation, blood sludging and tracer leakage from the capillaries of the stria vascularis are observed.When 400 mg/kg of hydrocortisone was injected, blood sludging occurred in 54% of the capillaries of the stria vascularis. With 150mg/kg of hydrocortisone, blood sludging occurred in 65%, and with 100mg/kg it occurred in 77% of the capillaries of the stria vascularis. When less than 50mg/kg hydrocortisone was administered, blood sludging occurred in 100% of the capillaries of the stria vascularis, as in the control animals. When a large dose of hydrocortisone was administered, HRP leakage also decreased.We conclude that hydrocortisone prevents blood sludging of the strial capillaries after decapitation, and suggest that it may be useful in improving the blood circulation of the strial capillaries.
耳鼻咽喉科臨床学会の論文