Glycoconjugates in normal nasal and maxillary mucosa and neoplasms.

概要

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Glycoconjugates in the nasal and maxillary mucosa of normal controls and of patients with inverted papilloma, epithelial dysplasia and carcinoma were studied by the lectins-HRP staining method. Four kinds of lectin were used: WGA, PNA, UEA-1, and RCA.1. Control nasal epithelium reacted to WGA and UEA-1. Some sugar residues stained with WGA, PNA, UEA-1 and RCA were detected in various amounts in the goblet cells and mucous cells of the subepithelial glands. Serous cells in the glands were stained by UEA-1.2. There was a similarity of WGA and UEA-1 staining in inverted papilloma, epithelial dysplasia, and control epithelium.3. Adenoid cystic carcinoma was not stained by any of the lectins. According to cellular differentiation, Squamous cell carcinoma showed various staining patterns depending on the degree of differentiation.4. Lectin staining may be a useful marker in the early diagnosis and cell differentiation of nasal and maxillary carcinomas.
耳鼻咽喉科臨床学会の論文