耳鼻咽喉科領域の神経ペプチドに関する免疫組織化学的研究-2-蝸牛血管における自律神経分布

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The distribution of peptidergic and adrenergic nerve fibers on the cochlear blood vessels was studied using the immunocytochemical and glyoxylic acid histofluorescence techniques (GA technique).In this study, the GA technique readily revealed numerous innervations of adrenergic nerve fibers on both labyrinthine and spiral modiolar arteries. Furthermore, we succeeded in showing the innervations of 4 kinds of peptidergic nerve fibers on the same arteries, which were, substance p (SP), vasoactive intestinal polypeptide (VIP), gastrin releasing peptide (GRP), and avian pancreatic polypeptide (APP). No nerve fibers were found in the stria vascularis.Denervation of the superior cervical ganglion caused reduction in the number of APP and adrenergic fibers on both labyrinthine and spiral modiolar arteries, but the number of the other 3 kinds of peptidergic nerve fibers was not influenced by the denervation.As a result of this study, it is speculated that peptidergic nerves together with adrenergic and cholinergic nerves play some important role in regulating the blood flow to the inner ear.
耳鼻咽喉科臨床学会の論文