顔面神経麻痺に対す薬剤効果の実験的検討-その2. メコバラミンおよびステロイド-

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Acute facial palsy was produced by compressing the extratemporal facial nerve of guinea pigs using a microsurgical needle holder.In the first group of 10 guinea pigs, 20mg/kg of methylprednisolone acetate was injected intramuscularly immediately after the compression and at weekly intervals. In the second group, 1000μg/Kg of methylcobalamin was injected immediately and every 48 hours. In the control group, the same amount of physiological saline was injected in the same manner as methylcobalamin.The grade of recovery of facial nerve function was assessed by the blink reflex and the evoked electromyogram of the orbicularis oculi muscle. Myelin obtained from the site of compression of the nerve was examined by light microscope.In the methylcobalamin and the steroid group, the blink reflex was restored significantly earlier than in the control group (Fig. 2). The evoked electromyographic response was restored about one week earlier in the methylcobalamin group than in the control group, and in the steroid group, even earlier restoration of the response was observed (Fig. 4). Histologically, the remyelination process progressed most rapidly in the steroid group (Fig. 6, 7 and 8).The results of the present investigation indicate that injection of either methylcobalamin or steroid accelerates repair of mechanical injury of the facial nerve. The methylcobalamin group showed a narrower distribution on the curative days than the steroid group. Therefore we assume that steroid is more effective for the selected nerves in this experiment, while methylcobalamin is moderately effective for all nerves without exception.

顔面神経麻痺に対す薬剤効果の実験的検討-その2. メコバラミンおよびステロイド-

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