Cisplatin ototoxicity.

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The electrophysiological and histopathological changes in the cochleas caused by the administration of cis-DDP (cis-diamminedichloroplatinum) were studied in guinea pigs. Hearing function was evaluated by ABR, and morphological studies were conducted by scanning electron microscope. The sensitivity of the cochlea to cis-DDP was dose-dependent. Hearing impairment was stronger in the group treated with a single high dose than in the group treated with multiple injections, and it was stronger in the group given 4 doses of 3mg/kg cis-DDP twice a week than in the group given 12 doses of 1mg/kg. Recovery of the ABR occurred in some animals given a single dose of 9mg/kg cis-DDP intramuscularly. The outer hair cells in the basal and second turns were mainly damaged, especially those in the first and the second rows. The inner hair cells were rarely damaged. There was a close correlation between the loss of cochlear hair cells and suppression of ABR; however, mild cochlear damage was observed in the guinea pigs which had no hearing impairment.
耳鼻咽喉科臨床学会の論文