Cancer of the oral mucosa in patient with Plummer-Vinson syndrome. Report of a case.:Report of a case

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Plummer-Vinson syndrome (PVS) has been known as one of the pre-cancerous conditions, especially because PVS patients have atropic mucous membrane that is excessive irritable. Recently, we experienced a case of PVS with three cancerous lesions in the oral cavity. The patient was a 57 year old female whose chief complaint was the swelling of right upper lip. In addition, she had a twenty years history of dysphagia. The oral cancerous lesions consisted of a thumb tip size tumor of the right upper lip mucosa, the same size tumor of the right cheek mucosa and a red bean size tumor of the right retromolar pad mucosa. Histopathologically, all of them were squamous cell carcinomas. A right submandibular lymph node was elongated. Another clinical findings were a red smooth tongue, fissuring at the commisures of lipand spoon-shaped nails. Laboratory findings revealed a typical iron deficiency anaemia. On barium swallow examination, esophageal web was recognized. The patient was treated by oral administration of iron therapy and the transfusion of concentrated red cells for the anaemia. The oral cancerous lesions were excised surgically after the preoperative radiation. There is no sign of recurrences of the oral lesions for one and a half years after surgery.
社団法人日本口腔外科学会の論文