Metabolic Fate of 3-(2-Methyl-4′-amino-pyrimidyl-(5′))-4-methyl-5-β-chloroethyl-thiazolium after Oral Administration
スポンサーリンク
概要
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1. The analysis of chlorothiamine was shown to be satisfactory by the ascending paper chromatography using n-butanol-acetic acid-water (4:1:1) as a solvent system, followed by the determination of separated thiamine, thiaminediphosphate and chlorothiamine. The conventional Decalso chromatography was found useful for determination of chlorothiamine.2. In case of the mixture of thiamine and chlorothiamine, the separation and identification of the compounds by paper chromatography were satisfactory with desirable recoveries.3. After oral administration of chlorothiamine to the operated birds, 17.3-24.6% of the compound was excreted in 12 hours.4. After oral administration of chlorothiamine- 35S NCI to the birds, 82% of 35S was found in urine and 18% in feces, the rest being undetectable. Total recovery of the unlabeled chlorothiamine was 23.6% in urine and 5.4% in feces, the rest being possibly converted to thiochrome-negative compounds.
- 日本ビタミン学会の論文
著者
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佐橋 佳一
Laboratory Biochemistry and Nutrition, Tokyo University of Agriculture
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鈴木 延義
Laboratory of Biochemistry and Nutrition, Department of Agricultural Chemistry, Tokyo Universty of Agriculture
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鈴木 隆雄
Laboratory of Biochemistry and Nutrition, Department of Agricultural Chemistry, Tokyo University of Agriculture
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鈴木 隆雄
Laboratory of Biochemistry and Nutrition, Department of Agricultural Chemistry, Tokyo Universty of Agriculture
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舛重 正一
Laboratory of Biochemistry and Nutrition, Department of Agricultural Chemistry, Tokyo Universty of Agriculture
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舛重 正一
Laboratory of Biochemistry and Nutrition, Department of Agricultural Chemistry, Tokyo University of Agriculture
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鈴木 隆雄
Laboratory Biochemistry and Nutrition, Tokyo University of Agriculture
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