Expression of major histocompatibility complex antigens in rat allografted bone tissue. Detect with monoclonal antibodies by immunohistochemistry.:detect with Monoclonal Antibodies by Immunohistochemistry

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The major histocompatibility complex antigen expressed in transplanted organs acts as both stimulators and targets in cells mediating rejection.In the organ allotranplantation it was reported that the nature of antigen, tissue location, and antigenic density may influence the course of development or intensity of the rejection process.The purpose of this study was to investigate modification of location and intensity of the MHC antigen expressing cells in allografted bone tissue using immunohistochemistry.Following conclusions were obtained through this study.(1) Some osteocytes expressed MHC Class I antigen in the normal rat bone tissue.(2) Expression of MHC Class I antigen in osteocytes showed diversity.(3) The expression of MHC Class I antigens in osteocytes on allografted bone tissue increased with time after bone allograft transplantation.(4) Three weeks after allograft transplantation, severe decrease of osteocytes on allografted bone tissue was investigated and almost all remaining osteocytes expressed MHC Class I antigen strongly on allografted bone tissue in DA to F344 strain combination.(5) MHC Class I antigens might play an important role in bone allograft rejection as seen in other organs in the rat.
西日本整形・災害外科学会の論文