Histochemical Study of Posterior Longitudinal Ligament Lesion in Zucker Fatty Rat.

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The Zucker fatty rat is used as an animal model to study ectopic ossification. The morbidity of OPLL in this adult rat is 23.8%. To evaluate the relationship between aging and the incidence of OPLL, we investigated the morbidity in elderly Zucker fatty rats and observed the localization of BMP-receptors in the ossification tissue by immunostaining. Four of 5 Zucker fatty rats had OPLL in their cervical spine, but only one of 4 control rats had OPLL. As the enchondral ossification site, the expression of BMPR-IA was strong while that of BMPR-II was weak. The expression of BMPR-IB was not detected. In the normal posterior longitudinal ligament of the Zucker fatty rat, We could only detect the expression of BMPR-IA, but in the control rat we could not defect any of these receptors. We concluded that Zuckerfatty rat is a useful animal model for evaluating OPLL because it has a hereditary disposition and the morbidity of OPLL increases with age.
西日本整形・災害外科学会の論文