ヒメマスのヘルペスウイルスNeVTAの細胞病理,ウイルス粒子形態および病原性

概要

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A nerka herpesvirus NeVTA (Nerka virus in Towada lake, Akita and Aomori prefecture), isolated from the kokanee salmon fry Oncorhynchus nerka in 1974, was examined for cytopathic effects including nucleus inclusion body and virion morphology using the negative stain method. The chracteristic of NeVTA infection exhibited the Cowdry type A inclusion body in nuclei of RTG-2 cells at 24 hour after the infection. The morphology of virion purified with CsCl density gradient centrifugation showed typical and fine structures being envelopes, capsidc and some of microstructures. The additional characterization of NeVTA was carried out on an experimental infection against salmonid fry for the basic evaluation of pathogenicity. The results suggested that higher susceptibility could occur in landlocked salmon species such as O. nerka and O. masou, but lower in seagoing salmon species O. keta, O. gorbuscha and trout species S. gairdneri. No mortality was observed in an experiment against charr S. fontinalis.