α-Mercaptopropionylglycine(α-MPG)およびSodium dipropylacetate(DPA)の抗体産生におよぼす影響-1-液性免疫反応におよぼす影響

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The humoral immuno-response : A study was carried out to determine the effect ot α-MPG and DPA on humoral antibody formation. The following results were obtained : The 1st and 2nd immuno-responses in rabbits to bacterial α-amylase were potentiated by treatment with both α-MPG and DPA given i. p. for 10 days after the 1st immunization, but the treatment after the 2nd immunization did not affect the 2nd immunoresponse. Formation of hemolytic plaque forming cells (HPFC) in the spleen of mice immunized with 5×10<SUP>8</SUP> sheep red blood cells (SRBC) was potentiated by the administration of the both drugs given i. p. for 5 days before or after the immunization. No appreciable formation of HPFC was observed by immunization with 5×10<SUP>6</SUP> SRBC, and here α-MPG or DPA were without effects. Immunization with more than 5×107 SRBC resulted in an increase of HPFC in a dose-dependent fashion. Such an increase was further reinforced by treatment with both drugs. HPFC increased with a single dose of α-MPG at 48 hr before or 24-72 hr after the immunization and also increased with that of DPA at 24 hr before or immediately after the SRBC treatment.
社団法人日本薬理学会の論文