Experimental studies on the positive tuberculin-anergia. (Part III):The accelaration of the phagocytotic action of blood plasma of the positive tuberculin-anergic guinea pigs and the complement-fixation-text of their sera.

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If we inject a minute dosis at first and gradually increase the dose of old tuberculin or defatted tubercle bacilli for tuberculous guinea pigs, some of them without causing undue loss of strength become tuberculin-negative by Römer's reaction.Investigation as to whether the blood plasma of the positive-tuberculin-anergic guinea pigs is able to accelarate the phagocytotic action of leucocytes (Otani's Method used) led to the following conclusions. a) Blood plasma obtained from the guinea pigs treated either with the defatted tubercle bacilli or old tuberculin have a strong accelarating power over the phagocytotic action. b) The plasma of guinea pigs treated with defatted tubercle bacilli is a little more powerful than that of guinea pigs treated with old tuberculin. c) Both blood plasma are however stronger in their action than the blood plasma of allergic guinea pig. The complement reaction of the sera was studied using the defatted tubercle bacillus as antigen. The content of the antibody is displayed in the following order: First, the serum obtained from the positive-tuberculin-anergic guinea pig treated with defatted tubercule bacilli; second, that of the animal treated with old tuber- culin; third, that of allergic tuberculous animal without treatment; and lastly the serum of uninfected guinea pigs have no specific complemental antibody.
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