REP使用下の結核性空洞の組織所見--1次剤使用例との対比

概要

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Histological features of tuberculous cavities of resected lungs treated with regimens of chemotherapy containing rifampicin were compared with that of patients treated with primary drugs by using the matched pair method. The following findings were noted as peculiar to lung specimens treated with rifampicin: 1. Gaseous material showed trend to be more concentrated and dehydrated. 2. Migration of many macrophages into caseous lesion which was followed by the digestion of necrotic debris by these macrophages. 3. Invasion of capillaries into caseous lesion. These findings suggest that caseous material becomes a foreign body already in the early stage of treatment due to very strong bactericidal activity of rifampicin and a foreign body is then degradated, ingested and organized.
一般社団法人日本結核病学会の論文