難治肺結核症に対するRFP隔日法の臨床
スポンサーリンク
概要
- 論文の詳細を見る
A regimen using Rifampicin every other day might be one of the proper regimen of RFP treatment, if the lag time of tubercle bacilli, the incidence of side-effects and the cost of the drug are taken into consideration. The RFP every other day regimen was applied to 36 cases of severe pulmonary tuberculosis who failed to be cured by chemotherapy and showing resistance to almost all anti-tuberculous drugs except EB. RFP in a dose of 450 mg was given every other day 60 minutes before the breakfast, and EB in a dose of 750 mg was given daily after the breakfast.<BR>After 6 months' treatment, tubercle bacilli in sputum converted to negative in 67% on culture. Among cases remained sputum positive, the emergence of RFP resistance was observed already 2 months after starting RFP treatment, and the majority of strains showed complete resistance to 50 mcg/m<I>l</I> RFP. Chest X-ray findings showed no changes in most of the cases.<BR>Two cases dropped out from the treatment; one case soon after starting treatment d ue to eruption, and another case at 5th month by death due to encephalomalacia. As the side-effects, albuminuria was seen in 5 cases, thrombocytopenia in 2 cases, and the increase of eosinophiles in 5 cases, and all of them were transient. Slight increase of serum transaminase was seen in 8 cases, and the slight elevation of serum bilirubin in 5 cases. Eight cases complained gastrointestinal disturbances, but all of them were slight and RFP was not interrupted.<BR>Summarizing the results mentioned above, a regimen using RFP every o t her day with EB daily could be evaluated as a effective and safe regimen.
- 一般社団法人 日本結核病学会の論文
著者
関連論文
- 20.過去2年間の自験肺癌症例120例の検討(第1報) : 第21回肺癌学会関西支部(関西支部)
- 135. 慢性呼吸不全患者とADL能力 : 阻害因子を中心として
- 83 循環器から見た呼吸リハビリテーションの効果
- 87 慢性呼吸器疾患の定量的評価の試み
- 13. 石綿ばく露者の量反応関係 (粉じん・じん肺)
- 10. 石綿肺症の肺機能障害 : 新旧じん肺法による肺機能検査成績 (粉じん・じん肺)
- M6-7 下気道感染の成立機序-慢性気道感染症 : 特に緑膿菌感染における IgA 系及び IgG の病態的意義について(気道感染の成立機序)
- 150) 臨床的に診断し得た心サルコイドーシスの1例 : 日本循環器学会第63回近畿地方会
- 瀰漫性肺疾患の診断における TBLB と BAL の有用性の検討(BAL か TBLB か, その適応と限界)
- 追加発言 BAL か TBLB か、その適応と限界
- 36 TBLB により診断しえた肺 Histiocytosis X の 1 例(症例 (I))
- 122 慢性気道疾患患者の血清 S-IgA 値(感染 (1))
- 石綿肺に合併した拡張型心筋症の1症例 : 日本循環器学会第64回近畿地方会
- 有機塵による呼吸障害
- 慢性気道疾患患者の喀痰中のフコースとシアル酸の分析
- 139 慢性閉塞性肺疾患患者の粘性痰中の粘液糖タンパクの糖鎖の分析(気道分泌)
- 138 気道 : 肺胞系のタンパク性生体防御成分に関する研究(気道分泌)
- 188. 経気管支性肺生検によるじん肺の診断 (粉じん,じん肺)
- Enviomycin (ツベラクチン) による肺結核治療
- 難治肺結核症に対するRFP隔日法の臨床