結核抗菌免疫 : 特にBCG Cell Wallによる実験を中心として
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It has been reported by Ribis research group in which the present author is included that intravenous injection of BCG cell wall (CW) attached to minute droplets of light mineral oil and uspended in saline produces pulmonary granuloma in mice that correlated with increased resistance against aerosol challenge with Mycobacterium tuberculosis, strain H<SUB>37</SUB>Rv.<BR>The present study was undertaken to examine an involvement of cell-mediated immunity in increased resistance against tuberculosis in mice immunized with BCG CW.<BR>The following results were obtained<BR>1) Lung cells from BCG CW-immunized mice showed macrophage migration inhibition (MIF) activity which are closely related with protection against aerosol challenge with H<SUB>37</SUB>Rv.<BR>2) Intravenous injection of specific antigen, PPD or BCG protoplasm, into BCG CW-immunized mice one day before aerosol challenge with <I>Mycobacterium bovis</I>, strain Ravenel, resulted in increased protection against the aerosol challenge.<BR>3) In order to explain the above mentioned phenomenon, various <I>in vitro</I> and <I>in vitro</I> experiments have been done. Results of these experiments are in favour of our assumption that interaction between sensitized lymphocytes and injected specific antigens releases lymphokaine in cluding MIF factor and possible macrophage activating factor into blood circulation which leads to destroy aerosal challenged-tubercle bacilli.<BR>4) Oil droplets containing P<SUB>3</SUB> (a nonantigenic, nonsensitizing trehalose mycolate isolated from <I>M. tuberculosis</I>) and an antigenically nonrelated protein, such as BAS, produced an extensive pulmonary granuloma 2 weeks after immunization that declined after 4 weeks, wheras at this time the slower acting BCG CW had developed a comparable granuloma. Accordingly, mice immunized with P<SUB>3</SUB>+BSA and challenged 2 weeks later were as well protected 4 weeks after challenge as were mice which had been immunized with BCG CW 4 weeks prior to challenge.<BR>5) We investigated the effect on pulmonary granuloma formation and protection in BCG CWimmunized mice of administration of specific antigens. Results of this experiment showed multiple intravenous injections of BCG protoplasm inhibited the footpad delayed hypersensitivity, MIF activity of lung cells and pulmonary granuloma formation as well as the induction of resistance against aerosol challenge with H<SUB>37</SUB>Rv.<BR>These results suggests that pulmonary granuloma formation is mediated by cellular immunity.<BR>In summary, antituberculous immunity induced with BCG CW in mice is closely associated with pulmonary granuloma which are considered to consist of massive activated macrophages resulting from cell-mediated immunity in lung tissue.
- 日本結核病学会の論文
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