腸内細菌のエピゾーム性耐性因子-37-R因子およびF因子の重感染免疫の機序

概要

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The mechanisms of superinfection immunity of R and F factors were studied in Escherichia coli K-12. Zygotic induction of phage γ and F-duction of gal+ were studied with an F'-gal-γ+ in recipients carrying F and R factors and found useful in elucidating the mechanisms of superinfection immunity of these episomes. The results obtained may be summarized as follows:1) The superinfection immunity of R and F factors occurs chiefly due to the inhibition of acceptance of these episomes on the cell surface and partly due to the mutual exclusion between homologous episomes inside the recipient bacteria. Thus, the superinfection immunity of these episomes is due to mechanisms fundamentally different from that of the immunity observed in temperate phages, which are caused by repressors.2) The superinfection immunity on the cell surface in these episomes can be reasonably accounted for by postulating specific receptors on the surface of recipient bacteria, to which the mating substances of donor bacteria are bound to form conjugation tubes.
日本細菌学会の論文