臨床分離非定型抗酸菌株の主要抗生物質感受性

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We determined the minimal inhibitory concentrations of the six antibiotics against the clinicallyisolated atypical mycobacterium strains, such as Mycobacterium intracellulare, M. kansasii, M. gordonae, M. fortuitum and M. nonchromogenicum in Dubos medium. Ampicillin was found to be effective to M.gordonae, M. nonchromogenicum and M. intracellulare, but not effective to M. kansasii and M. fortuitum.Cephalexin was a little less effective than ampicillin. Streptomycin and tetracycline were found tobe similarly effective to M. gordonae and to some of the strains of M. kansasii and M. intracellulare, thoughtetracycline was found to be more effective to M. fortuitum than streptomycin, and streptomycin wasfound to be more effective to M. kansasii than tetracycline. Chloramphenicol and erythromycin werefound to be effective only to M. gordonae.<BR>Since mycobacteria grow intracellulary and cause granulomatous inflammation, in vitro resultsmay not directly agree with the clinical effectiveness. But, we found at least in vitro that even ampicillin could be effective against atypical mycobacteria located extracellulary, and that tetracyclinecould be as effective as streptomycin.
日本結核病学会の論文