抗酸性菌による非特異的感染抵抗性に関する研究 : III BCG石炭酸死菌前処置マウス体内におけるStaph. aureusの運命につて

概要

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The mechanisms of the heterologous immunity of phenol-killed BCG treated mice against staphylococcul infection was not clear as yet. As a help for elucidating this mechanism, the behaviors of Staphylococcus aureus in the kidney of phenol-killed BCG treated and untreated mice were compared.At first, the course of experimental infection with Staphylococcus aureus in the tissue of untreated mice was studied. In the lungs, liver and spleen, the population of culturable staphylococci showed a gradual decline when sampled at various times after infection. However, the fate of this organism in mouse kidney showed a sharp increase until the first two days.From the results of these experiments, the behaviors of Staphylococcus aureus in the kidney of phenolkilled BCG treated mice, the population of staphylococci showed an increase. Neverthless, in the kidny of phenol-killed BCG treated mice, the growth of this organism was suppressed during the observation period.This finding suggested that the resistance of phenol-killed BCG treated mice against staphylococcal infection was due to the growth suppression by this organism in the kidney.
日本細菌学会の論文