抗酸性菌による非特異的感染抵抗性に関する研究 : I. 石炭酸死菌の抵抗性増強作用

概要

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Phenol-killed cells of various strains of mycobacteria increased the resistance of mice against the lethal infection of virulent staphylococci. In this subsequent studies, the phenomenum of heterologous immunogenicity has been investigated in details.<BR>Resistance of mice against staphylococcal infection was increased by the immunization with either intraperitoneal or subcutaneous injection of phenol-killed BCG cells. As far as protective effectis concerned, intraperitoneal injection afforded better protection than subcutaneous one. As to the material used for cell suspension, phenol-killed BCG cells suspended in Drakeol gave high immunogenicity than the cells suspended in distilled water. Heterologous immunogenic activity was obtained at the doses lower than 0.001 mg in the case of Drakeol suspension, whereas 0.1mg for intraperitoneous or 1mg for subcutaneous route is necessary to obtain comparative immunogenicity in the case of water suspension.<BR>The resistance of mice against the infection persisted for two to three weeks, reaching its highest activity at the third to fifth day after the injection of killed cells.<BR>This protective effect of BCGcells extended not only against infection of Gram-positive bacteria but also against attack of Gram-negative bacteria.
日本細菌学会の論文