OXYGEN POISONING AND VITAMIN E DEFICIENCY

概要

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This study was undertaken to examine the effects of oxygen exposure on vitamin E deficiency in mice. After 20 hr of exposure to pure oxygen, 5 of 7 mice in the vitamin E deficient group died, but only 1 of 7 in the vitamin E supplemented group died. Pulmonary atelectasis and hemor-rhages were the common features in the mice that died. Of the surviving mice, those in the vitamin E deficient group had partial hemorrhages, but those in the control group had no significant pathological changes. A reduction in phospholipid and sulfhydryl groups was observed in the supernatant fractions of the lungs of vitamin E deficient mice. After oxygen exposure further reductions occurred in both groups of mice, but more predominantly in the vitamin E deficient group. In the sediment fraction of the lungs, similar changes were found in the phospholipids in the vitamin E deficient group before and after exposure to oxygen. The sulfhydryl groups in the sediment fractions were decreased signi-ficantly in the vitamin E deficient group after oxygen exposure, but they remained unchanged in the control group.
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