Comparative changes in plasma and RBC .ALPHA.-tocopherol after administration of dl-.ALPHA.-tocopheryl acetate and d-.ALPHA.-tocopherol.

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Changes in plasma and RBC α-tocopherol after intravenous and oral administration of dl-α-tocopheryl acetate were investigated using vitamin E-deficient rats and were compared with those following the administration of d-α-tocopherol, which is the most active and natural form of tocopherol. 1. Intravenous administration: By the administration of dl-tocopheryl acetate, the elevated plasma tocopherol levels were higher at 6h than those elevated by d tocopherol, but the RBC tocopherol was lower 6 h after the infusion of dl-tocopheryl acetate than after d tocopherol infusion. The tocopheryl acetate incorporated into the RBCs remained for 24h after the administration of tocopheryl acetate, the acetate then becoming undetect-able in plasma. 2. Oral administration: The tocopherol elevated in plasma and RBC was only the α-form and not tocopheryl acetate. In both plasma and RBCs, tocopherol levels were higher after the administration of d tocopherol than after dl-tocopheryl acetate administration, and more was found in RBCs.
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