EFFECT OF SUCCINIC SEMIALDEHYDE ON SEIZURE CAUSED BY VITAMIN B6 ANTAGONISTS
スポンサーリンク
概要
- 論文の詳細を見る
Since γ-hydroxybutyric acid (GHB) is known to be an effective anesthetic adjuvant in animal and a natural metabolite of succinic semialdehyde (SSA), the effect of SSA and GHB on the convul sive action of vitamin B6 antagonists was studied using the onset of seizure as a parameter. The administration of SSA and GHB to mice protected them against the convulsive action of B6 antagonist, such as castrix (2-chloro-4-dimethyl-6 methylpyrimidine), thiosemicarbazide, or penicillamine. The anticonvulsant effect of SSA seems to be due to an increase in brain levels of GHB converted in vivo from SSA.
- 財団法人 学会誌刊行センターの論文
著者
-
川又 いつ子
慈恵会医大医化学
-
松田 誠
Department of Biochemistry, The Jikei University School of Medicine
-
川又 いつ子
Department of Biochemistry, Jikei University School of Medicine
関連論文
- 2.ビタミンB_6拮抗剤によるけいれんに対するサクシニックセミアルデヒドの影響(JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY Vol.22 No.4(掲載論文要旨))
- 5.ビタミンB_6欠乏ケイレンに対するSuccinic semialdehydeの影響(ビタミンB研究委員会 : 第225回会議研究発表要旨)
- The Effects of Administration of Semicarbazide and Aminooxyacetic Acid on B6 Vitamer Levels in Subcellular Fractions of Mouse Brain
- RELEASE OF γ-AMINOBUTYRIC ACID FROM ISOLATED BRAIN SYNAPTOSOMES DURING SEMICARBAZIDE-INDUCED CONVULSIONS
- EFFECT OF SUCCINIC SEMIALDEHYDE ON SEIZURE CAUSED BY VITAMIN B6 ANTAGONISTS
- EFFECTS OF PENICILLAMINE ON DISTRIBUTION OF B6 VITAMERS IN RAT URINE
- EFFECT OF PYRIDOXAL ADMINISTRATION ON THE CONTENTS OF PYRIDOXAL PHOSPHATE AND γ-AMINOBUTYRIC ACID IN MOUSE BRAIN
- EFFECT OF ANTIVITAIN B6 ON REGIONAL GABA METABOLISM IN MOUSE BRAIN AND ITS RELATION TO CONVULSIONS
- THE EFFECT OF ANTIVITAMIN B6 ADMINISTRATION ON γ-AMINOBUTYRIC ACID METABOLISM IN RETINA AND ELECTRORETINOGRAM
- EFFECTS OF PENICILLAMINE ON THE CONTENTS OF B6 VITAMERS OF THE MOUSE BRAIN
- Transport and metabolism of pyridoxine and pyridoxal in mice.
- Transport and metabolism of pyridoxine in the intestine of the mouse.