EFFECT OF PYRIDOXAL ADMINISTRATION ON THE CONTENTS OF PYRIDOXAL PHOSPHATE AND γ-AMINOBUTYRIC ACID IN MOUSE BRAIN

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概要

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• Many mice treated with a high single dose of PL died in convulsions. The convulsions were very similar to those induced with some anti B6 in several ways: (1) a long latent period occurs before convulsions; (2) PLP levels in brain decrease; (3) GABA levels in brain, especially in synaptosomal fraction, decrease. The possibility that a deranged GABA metabolism in nerve ending may be a major cause of the convulsions is discussed.

• 財団法人 学会誌刊行センターの論文

著者

• 衛藤 公治

  慈恵医大 医化

• 桜井 多恵

  Department of Biochemistry, The Jikei University School of Medicine

• 松田 誠

  Department of Biochemistry, The Jikei University School of Medicine

• 星野 道雄

  Department of Biochemistry, The Jikei University School of Medicine

• 衛藤 公治

  Department o f Internal Medicine, 3rd Hospital, The Jikei University School of Medicine

• 高橋 康子

  Department o f Internal Medicine, 3rd Hospital, The Jikei University School of Medicine

• 桜井 多恵

  Department o f Internal Medicine, 3rd Hospital, The Jikei University School of Medicine

• 星野 道雄

  Department o f Internal Medicine, 3rd Hospital, The Jikei University School of Medicine

関連論文

• 6.マウス脳内PLP, γ-アミノ酪酸量に及ぼすピリドキサル投与の影響(JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY : 掲載論文要旨)
• 15.ビタミンB_6過剰投与による脳内ビタミンB_6量及びγ-アミノ酪酸量の変化(ビタミンB研究委員会 : 第241回会議研究発表要旨)
• The Effects of Administration of Semicarbazide and Aminooxyacetic Acid on B6 Vitamer Levels in Subcellular Fractions of Mouse Brain
• RELEASE OF γ-AMINOBUTYRIC ACID FROM ISOLATED BRAIN SYNAPTOSOMES DURING SEMICARBAZIDE-INDUCED CONVULSIONS
• EFFECT OF SUCCINIC SEMIALDEHYDE ON SEIZURE CAUSED BY VITAMIN B6 ANTAGONISTS
• EFFECTS OF PENICILLAMINE ON DISTRIBUTION OF B6 VITAMERS IN RAT URINE
• EFFECT OF PYRIDOXAL ADMINISTRATION ON THE CONTENTS OF PYRIDOXAL PHOSPHATE AND γ-AMINOBUTYRIC ACID IN MOUSE BRAIN
• EFFECT OF ANTIVITAIN B6 ON REGIONAL GABA METABOLISM IN MOUSE BRAIN AND ITS RELATION TO CONVULSIONS
• THE EFFECT OF ANTIVITAMIN B6 ADMINISTRATION ON γ-AMINOBUTYRIC ACID METABOLISM IN RETINA AND ELECTRORETINOGRAM
• EFFECTS OF PENICILLAMINE ON THE CONTENTS OF B6 VITAMERS OF THE MOUSE BRAIN
• Transport and metabolism of pyridoxine and pyridoxal in mice.
• Transport and metabolism of pyridoxine in the intestine of the mouse.

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