Effect of indigestible polysaccharides on pancreatic exocrine secretion and biliary output.

概要

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The present study was designed to determine the effect of purified viscous polysaccharides on pancreatic exocrine secretion and biliary output. Male Sprague-Dawley rats aged 5 weeks were fed either on the control diet which contained no fiber or on the experimental diets that contained 5 % indigestible polysaccharides (agar, ic-carrageenan, Naalginate and konjac mannan). After pretreatment with each diet for 2 weeks, the diet was discontinued overnight, and the animals were then allowed to eat 4 g of the test diet in 1 h. Immediately after this, a polyethylene tube was placed in the common bile duct, under anesthesia. Combined, free drained pancreatic-bile juice was collected for the following l h. Long-term (2 weeks) administration of Na-alginate and konjac mannan gave rise to increases in the volume of secreted juice and in the output of total bile acids, amylase and protease, whereas that of agar and K-carrageenan had no affect. Since a single dose of Na-alginate and konjac mannan was ineffective as regards pancreatic-bile secretion, the elevated secretion observed over prolonged periods may result from processes of adaptation against highly viscous polysaccharides.
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