Effects of various combinations of .OMEGA.3 and .OMEGA.6 polyunsaturated fats with saturated fat on serum lipid levels and eicosanoid production in rats.

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The effects of varying the ratio of polyunsaturated/saturated fatty acids (P/S) and ω3/ω6 polyunsaturated fatty acids (PUFA) of dietary fats on lipid metabolism were studied in rats using safflower oil (SF0), linseed oil (LSO), palm oil (PLO), and a 1:1 com-bination of these oils. The hypocholesterolemic and hypotriglyceride-mic effects depended on the P/S ratio of dietary fats, LSO (ω3 PUFA) being more effective than SFO (ω6 PUFA). A similar pattern of the response was observed on liver cholesterol and triglyceride. The liver cholesterol-lowering effect of LSO, but not SFO, remained even when they were combined with PLO. The activity of liver Δ6-desaturase tended to be higher while that of liver phospholipase A2 was significantly lower in the LSO group than in the SFO or PLO groups. The aortic PGI2 production and the production by platelets of thromboxane A2 were significantly low in rats fed LSO accompanying a distinct reduction of arachidonate in tissue phospholipids. The depressing effect of LSO disappeared when it was combined with SFO but not with PLO. There were no significant differences in enzyme activities and eicosanoid production between SFO and PLO in spite of a large difference in their P/S ratio. Thus, lipid parameters examined were complicatedly regulated by the ratios of ω3/ω6 as well as P/S, suggesting an existence of an appropriate ratio for these variables.
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