Retinoids and Related Compounds. Part 12. Optical Resolution of(.+-.)-All-trans-3-Hydroxyretinal by Use of High-Performance Liquid Chromatography.
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概要
- 論文の詳細を見る
Racemic all-trans-3-hydroxyretinal (3-OH-RAL) (1) was converted by a reaction with (-)-camphanic acid chloride (CpCl) into a diastereomixture of camphanates (2a) and (2b) which was separated by preparative high-performance liquid chromatography (HPLC) to give two esters (2a) and (2b) in pure state, respectively. Saponification of (2a) and (2b) independently afforded optically active (3S)- and (3R)-3-OH-RALs (3a) and (3b), respectively, whose absolute structures were determined by circular dichroism (CD) spectra. Racemic 3-OH-RAL was separated to two peaks by HPLC using chiral column (ChiraSpher, Merck). Cochromatographywith authentic specimens (3a) and (3b) showed that the peak with ashort retention time corresponded to (3R )-isomer and the other to (3S).
著者
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Ito Masayoshi
Kobe College Pharm.
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TSUKIDA Kiyoshi
Kobe Women's College of Pharmacy
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KATSUTA (née
Kobe Women's College of Pharmacy
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OKANO Aiko
Kobe Women's College of Pharmacy
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MURAKAMI Makiko
Kobe Women's College of Pharmacy
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KATSUTA (née
Kobe Women's College of Pharmacy
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KOYAMA Mayumi
Kobe Women's College of Pharmacy
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IWAKI Naoko
Kobe Women's College of Pharmacy
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IWAKI Naoko
Kobe Women's College of Pharmacy
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KATSUTA (née
Kobe Women's College of Pharmacy
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KOYAMA Mayumi
Kobe Women's College of Pharmacy
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